Biomolecular Chemistry in Liquid Phase Separated Compartments

Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism

P granules are non-membrane-bound RNA-protein compartments that are involved in germline development in C. elegans. They are liquids that condense at one end of the embryo by localized phase separation, driven by gradients of polarity proteins such as the mRNA-binding protein MEX-5. To probe how polarity proteins regulate phase separation, we combined biochemistry and theoretical modeling. We r...

Organic and Biomolecular Chemistry

Vitrification and Crystallization of Phase-Separated Metallic Liquid

The liquid–liquid phase separation (LLPS) behavior of Fe50Cu50 melt from 3500 K to 300 K with different rapid quenching is investigated by molecular dynamics (MD) simulation based on the embedded atom method (EAM). The liquid undergoes metastable phase separation by spinodal decomposition in the undercooled regime and subsequently solidifies into three different Fe-rich microstructures: the int...

Phase Inversion in a Batch Liquid – Liquid Stirred System

"> Phase inversion phenomenon occurs in many industrial processes including liquidliquid dispersions. Some parameters such as energy input or the presence of mineral compounds in the system affect this phen...

Perspectives on moving ionic liquid chemistry into the solid phase.

Ionic liquid (IL) chemistry has evolved over the past century, such that these organic salts have impacted virtually every area of science and engineering. In the area of chemistry, initial applications of these salts were primarily the domain of chemists or chemical engineers who desired to manipulate the properties of IL solvents for a variety of applications including tuning various chemical...